:root {
  --ink: #11203b;
  --muted: #68758a;
  --line: #dce2ec;
  --line-strong: #c6ceda;
  --surface: #ffffff;
  --canvas: #f5f7fb;
  --indigo: #434cf2;
  --indigo-dark: #3339d9;
  --indigo-soft: #eef0ff;
  --green: #0d9760;
  --green-soft: #eaf8f1;
  --danger: #a72b37;
  --shadow: 0 12px 30px rgba(24, 39, 75, 0.07), 0 2px 6px rgba(24, 39, 75, 0.05);
}

* { box-sizing: border-box; }
html { min-width: 320px; background: var(--canvas); }
body { margin: 0; background: radial-gradient(circle at 70% 5%, rgba(67, 76, 242, 0.06), transparent 28rem), var(--canvas); color: var(--ink); font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif; }
button, input, select { font: inherit; }
button, summary, select, input { -webkit-tap-highlight-color: transparent; }
button:focus-visible, summary:focus-visible, select:focus-visible, input:focus-visible { outline: 3px solid rgba(67, 76, 242, 0.22); outline-offset: 2px; }
[hidden] { display: none !important; }
.app-shell { min-height: 100vh; padding-bottom: calc(42px + env(safe-area-inset-bottom)); }
.app-header { display: flex; align-items: center; justify-content: space-between; gap: 20px; min-height: 98px; padding: calc(20px + env(safe-area-inset-top)) clamp(20px, 4vw, 56px) 18px; border-bottom: 1px solid rgba(220, 226, 236, 0.8); background: rgba(255, 255, 255, 0.82); backdrop-filter: blur(16px); }
.brand-block { display: flex; align-items: center; gap: 14px; min-width: 0; }
.brand-mark { display: grid; flex: 0 0 auto; place-items: center; width: 46px; height: 46px; border-radius: 14px; background: linear-gradient(145deg, #6269ff, #343ce1); box-shadow: 0 8px 20px rgba(67, 76, 242, 0.24); color: white; font-size: 14px; font-weight: 800; }
.brand-block h1 { margin: 0; font-size: clamp(23px, 2.5vw, 33px); letter-spacing: -0.035em; }
.brand-block p { margin: 4px 0 0; color: var(--muted); font-size: 12px; }
.dataset-badge { flex: 0 0 auto; padding: 9px 13px; border: 1px solid #d8dcff; border-radius: 11px; background: var(--indigo-soft); color: var(--indigo-dark); font-size: 13px; font-weight: 700; }
.privacy-banner, .dataset-card, .workspace-grid { width: min(1380px, calc(100% - clamp(32px, 8vw, 112px))); margin-inline: auto; }
.privacy-banner { display: flex; align-items: center; gap: 10px; margin-top: 19px; padding: 11px 14px; border: 1px solid #c8e8d8; border-radius: 12px; background: var(--green-soft); color: #176846; font-size: 13px; }
.privacy-banner > span { display: grid; flex: 0 0 auto; place-items: center; width: 23px; height: 23px; border-radius: 50%; background: #ccefdc; color: #08784a; font-weight: 800; }
.privacy-banner p { margin: 0; line-height: 1.45; }
.dataset-card { display: flex; align-items: center; justify-content: space-between; gap: 24px; margin-top: 15px; padding: 18px 20px; border: 1px solid var(--line); border-radius: 16px; background: rgba(255, 255, 255, 0.94); box-shadow: var(--shadow); }
.eyebrow { margin: 0 0 5px; color: var(--indigo); font-size: 11px; font-weight: 800; letter-spacing: 0.11em; text-transform: uppercase; }
.dataset-card h2, .results-heading h2, .table-heading h3 { margin: 0; letter-spacing: -0.025em; }
.dataset-card h2 { font-size: 20px; }
.dataset-card p:not(.eyebrow) { margin: 5px 0 0; color: var(--muted); font-size: 12px; }
.dataset-actions { display: flex; flex-wrap: wrap; gap: 9px; justify-content: flex-end; }
.primary-button, .secondary-button, .ghost-button { min-height: 43px; padding: 0 16px; border-radius: 9px; font-weight: 700; cursor: pointer; }
.primary-button { border: 1px solid var(--indigo); background: linear-gradient(135deg, #5058f6, #373fe7); box-shadow: 0 7px 15px rgba(67, 76, 242, 0.2); color: white; }
.secondary-button { border: 1px solid #d8aeb3; background: #fff8f8; color: var(--danger); }
.ghost-button { border: 1px solid transparent; background: transparent; color: var(--indigo); }
.tabs { display: flex; gap: 12px; height: 64px; margin-top: 15px; padding: 0 clamp(20px, 4vw, 56px); border-block: 1px solid var(--line); background: rgba(255, 255, 255, 0.76); }
.tabs button { position: relative; min-width: 120px; padding: 0 18px; border: 0; background: transparent; color: #4c5870; font-weight: 700; cursor: pointer; }
.tabs button::after { content: ""; position: absolute; right: 8px; bottom: -1px; left: 8px; height: 3px; border-radius: 4px 4px 0 0; background: transparent; }
.tabs button.active { color: var(--indigo); }
.tabs button.active::after { background: var(--indigo); }
.workspace-grid { display: grid; grid-template-columns: minmax(290px, 360px) minmax(0, 1fr); gap: 26px; margin-top: 26px; align-items: start; }
.filter-card, .metric-card, .table-card, .ac-controls { border: 1px solid var(--line); background: rgba(255, 255, 255, 0.95); box-shadow: var(--shadow); }
.filter-card { position: sticky; top: 16px; border-radius: 17px; }
.filter-card > summary { display: flex; align-items: center; justify-content: space-between; min-height: 64px; padding: 0 20px; list-style: none; font-size: 20px; font-weight: 750; cursor: pointer; }
.filter-card > summary::-webkit-details-marker { display: none; }
.filter-card > summary b { display: inline-grid; place-items: center; min-width: 23px; height: 23px; margin-left: 7px; padding: 0 6px; border-radius: 99px; background: var(--indigo-soft); color: var(--indigo); font-size: 11px; }
.filter-body { display: grid; gap: 14px; padding: 0 20px 20px; }
.field-group { display: grid; gap: 7px; margin: 0; padding: 0; border: 0; color: #31405a; font-size: 13px; font-weight: 650; }
.field-group legend { padding: 0; }
.field-group select, .field-group input, .multi-select > summary { width: 100%; min-height: 43px; padding: 0 11px; border: 1px solid var(--line-strong); border-radius: 9px; background: white; color: #27344b; }
.date-row { display: grid; grid-template-columns: 1fr 1fr; gap: 9px; }
.date-row label { display: grid; gap: 5px; color: var(--muted); font-size: 11px; }
.segmented { display: flex; overflow: hidden; border: 1px solid var(--line-strong); border-radius: 9px; background: white; }
.segmented button { flex: 1; min-height: 41px; padding: 0 10px; border: 0; border-right: 1px solid var(--line-strong); background: transparent; color: #566278; font-size: 12px; font-weight: 650; cursor: pointer; }
.segmented button:last-child { border-right: 0; }
.segmented button.active { background: var(--indigo-soft); color: var(--indigo); box-shadow: inset 0 0 0 1px #7d84ff; }
.multi-select { position: relative; }
.multi-select > summary { display: flex; align-items: center; justify-content: space-between; list-style: none; cursor: pointer; }
.multi-select > summary::-webkit-details-marker { display: none; }
.multi-menu { position: absolute; z-index: 10; top: calc(100% + 7px); right: 0; left: 0; max-height: 310px; overflow: auto; padding: 8px; border: 1px solid var(--line); border-radius: 12px; background: white; box-shadow: 0 18px 38px rgba(28, 39, 69, 0.16); }
.multi-menu-heading { display: flex; align-items: center; justify-content: space-between; padding: 5px 4px 8px; font-size: 12px; }
.multi-menu-heading button { border: 0; background: transparent; color: var(--indigo); font-weight: 700; }
.multi-menu > input { margin-bottom: 6px; }
#microorganismOptions label { display: flex; align-items: center; gap: 9px; min-height: 38px; padding: 6px 5px; border-radius: 7px; font-size: 12px; font-weight: 500; }
#microorganismOptions label:active { background: #f4f5fb; }
#microorganismOptions input { width: 17px; min-height: 17px; padding: 0; accent-color: var(--indigo); }
.filter-actions { display: grid; grid-template-columns: 1.2fr 1fr; gap: 8px; margin-top: 3px; }
.results-area { min-width: 0; }
.results-heading { display: flex; align-items: end; justify-content: space-between; gap: 18px; min-height: 56px; margin-bottom: 13px; }
.results-heading h2 { font-size: 27px; }
.grouping-field { display: grid; gap: 4px; color: var(--muted); font-size: 11px; }
.grouping-field select { min-height: 38px; padding: 0 30px 0 10px; border: 1px solid var(--line-strong); border-radius: 8px; background: white; color: #29374e; }
.rule-note { margin: 0 0 4px; color: var(--muted); font-size: 12px; }
.metric-grid { display: grid; grid-template-columns: 1.6fr 0.9fr 1fr; gap: 14px; }
.metric-card { display: flex; flex-direction: column; min-height: 160px; padding: 21px; border-radius: 16px; }
.metric-card > span { color: #40506a; font-size: 14px; font-weight: 700; }
.metric-card strong { margin: 12px 0 auto; color: #0f1e38; font-size: clamp(35px, 4vw, 54px); letter-spacing: -0.045em; line-height: 1; }
.metric-card .period-value { font-size: clamp(25px, 3vw, 37px); }
.metric-card small { margin-top: 13px; color: var(--muted); font-size: 11px; }
.metric-primary small { color: var(--green); font-weight: 700; }
.table-card { margin-top: 16px; overflow: hidden; border-radius: 17px; }
.table-heading { display: flex; align-items: flex-start; justify-content: space-between; gap: 16px; padding: 20px 22px 16px; }
.table-heading h3 { font-size: 20px; }
.table-heading p { margin: 5px 0 0; color: var(--muted); font-size: 12px; }
.ranking-table { padding: 0 22px 16px; }
.ranking-row { display: grid; grid-template-columns: minmax(155px, 1.5fr) 55px 58px minmax(90px, 1fr); gap: 12px; align-items: center; min-height: 50px; border-top: 1px solid var(--line); font-size: 13px; }
.ranking-row strong { min-width: 0; overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.ranking-header-row { min-height: 37px; border-top: 0; color: var(--muted); font-size: 10px; font-weight: 750; letter-spacing: 0.05em; text-transform: uppercase; }
.bar-track { display: block; height: 9px; overflow: hidden; border-radius: 99px; background: #eef0fb; }
.bar-track i { display: block; height: 100%; border-radius: inherit; background: linear-gradient(90deg, #afb4f7, #858ded); }
.empty-state { padding: 35px 15px; border-top: 1px solid var(--line); color: var(--muted); text-align: center; }
.ac-controls { display: grid; grid-template-columns: 1.2fr 1fr 0.9fr; gap: 16px; padding: 18px 20px; border-radius: 16px; }
.ac-controls label, .ac-controls fieldset { display: grid; gap: 7px; min-width: 0; margin: 0; padding: 0; border: 0; color: #425069; font-size: 12px; font-weight: 650; }
.ac-controls select, .ac-controls input { width: 100%; min-height: 43px; padding: 0 11px; border: 1px solid var(--line-strong); border-radius: 9px; background: white; color: #29374e; }
.organism-tags { display: flex; flex-wrap: wrap; gap: 6px; }
.organism-tags span { padding: 6px 9px; border-radius: 99px; background: var(--indigo-soft); color: var(--indigo); font-size: 11px; font-weight: 700; }
.ac-table { padding: 0 22px 16px; }
.ac-row { display: grid; grid-template-columns: minmax(180px, 1.4fr) 70px 60px 60px 58px minmax(120px, 0.9fr); gap: 10px; align-items: center; min-height: 53px; border-top: 1px solid var(--line); font-size: 12px; }
.ac-row b { font-weight: 800; }
.ac-header-row { min-height: 38px; border-top: 0; color: var(--muted); font-size: 10px; font-weight: 750; letter-spacing: 0.04em; text-transform: uppercase; }
.ac-row.low-sample { color: #7d8798; background: linear-gradient(90deg, rgba(244, 245, 248, 0.7), transparent); }
.ac-row.low-sample b { color: #6e7889; }
.ac-row.sensitivity-emerald { background: linear-gradient(90deg, rgba(0, 155, 119, 0.10), transparent 72%); }
.ac-row.sensitivity-emerald b { color: #008a6a; }
.ac-row.sensitivity-light-green { background: linear-gradient(90deg, rgba(123, 201, 111, 0.13), transparent 72%); }
.ac-row.sensitivity-light-green b { color: #4e9b43; }
.ac-row.sensitivity-yellow { background: linear-gradient(90deg, rgba(244, 197, 66, 0.16), transparent 72%); }
.ac-row.sensitivity-yellow b { color: #a97000; }
.ac-row.sensitivity-red { background: linear-gradient(90deg, rgba(229, 57, 53, 0.10), transparent 72%); }
.ac-row.sensitivity-red b { color: #d32f2f; }
.toast { position: fixed; z-index: 50; right: 18px; bottom: calc(18px + env(safe-area-inset-bottom)); max-width: min(420px, calc(100% - 36px)); padding: 13px 16px; border-radius: 11px; background: #172640; box-shadow: 0 12px 30px rgba(10, 20, 40, 0.25); color: white; font-size: 13px; }
.toast[data-error="true"] { background: #8f2631; }

@media (max-width: 930px) {
  .workspace-grid { grid-template-columns: 1fr; }
  .filter-card { position: static; }
  .metric-grid { grid-template-columns: 1.35fr 1fr 1fr; }
}

@media (max-width: 680px) {
  .app-header { align-items: flex-start; min-height: auto; padding: calc(16px + env(safe-area-inset-top)) 16px 14px; }
  .brand-mark { width: 40px; height: 40px; border-radius: 12px; }
  .brand-block h1 { font-size: 20px; }
  .brand-block p { font-size: 10px; }
  .dataset-badge { padding: 7px 9px; font-size: 10px; }
  .privacy-banner, .dataset-card, .workspace-grid { width: calc(100% - 24px); }
  .privacy-banner { align-items: flex-start; margin-top: 12px; font-size: 11px; }
  .dataset-card { align-items: stretch; flex-direction: column; gap: 14px; padding: 16px; }
  .dataset-actions { display: grid; grid-template-columns: 1fr; }
  .tabs { height: 58px; margin-top: 12px; padding: 0 10px; }
  .tabs button { min-width: 0; flex: 1; padding: 0 8px; }
  .workspace-grid { gap: 18px; margin-top: 16px; }
  .filter-card > summary { min-height: 58px; padding: 0 16px; font-size: 18px; }
  .filter-body { padding: 0 16px 16px; }
  .results-heading { align-items: flex-start; flex-direction: column; gap: 8px; }
  .results-heading h2 { font-size: 24px; }
  .metric-grid { grid-template-columns: 1fr 1fr; gap: 10px; }
  .metric-card { min-height: 132px; padding: 17px; }
  .metric-card:first-child { grid-column: 1 / -1; }
  .metric-card strong { font-size: 40px; }
  .metric-card .period-value { font-size: 27px; }
  .table-heading { padding: 17px 16px 13px; }
  .ranking-table { padding: 0 16px 13px; }
  .ranking-row { grid-template-columns: minmax(125px, 1fr) 42px 48px; gap: 7px; min-height: 48px; }
  .ranking-row .bar-track, .ranking-header-row span:last-child { display: none; }
  .ac-controls { grid-template-columns: 1fr; padding: 16px; }
  .ac-table { padding: 0 14px 12px; }
  .ac-header-row { display: none; }
  .ac-row { grid-template-columns: 1fr repeat(2, auto); gap: 7px 12px; padding: 12px 2px; }
  .ac-row strong { grid-column: 1 / -1; font-size: 14px; }
  .ac-row span { display: flex; gap: 5px; align-items: baseline; }
  .ac-row span::before { content: attr(data-label); color: var(--muted); font-size: 9px; font-weight: 750; text-transform: uppercase; }
  .organism-tags { justify-content: flex-start; }
}